Principal Scientist jobs in San Francisco — demand, required skills, and comparable metros (2026)
As of 2026-05-17, Skillenai has indexed 4 Principal Scientist postings located in San Francisco over the past 90 days. The skill mentioned most often is Active learning.
Last updated · 90d ending 2026-05-17
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Frequently asked questions about Principal Scientist jobs in San Francisco
+Are Principal Scientist jobs being posted in San Francisco right now?
Yes. Skillenai has indexed 4 Principal Scientist postings located in San Francisco over the 90 days ending 2026-05-17.
+What skills do Principal Scientist jobs in San Francisco require?
Across Principal Scientist postings in San Francisco indexed by Skillenai over the 90 days ending 2026-05-17, the skills mentioned most often are Active learning, generative models, structure prediction, Structural biology, high-throughput experiments.
+Which other cities are hiring Principal Scientist?
As of 2026-05-17, the metro areas posting the most Principal Scientist jobs outside San Francisco are Boston, Seattle, Beijing, Cambridge, London, based on the Skillenai jobs index.
+How can I get notified about new Principal Scientist jobs in San Francisco?
Skillenai sends a daily email digest of new Principal Scientist postings as they're indexed across the open web. Set up a saved search filtered to San Francisco from your account dashboard after creating a free Skillenai account.
Weekly Principal Scientist postings in San Francisco — last 90 days
Skills most often required for Principal Scientist in San Francisco
| Name | Postings | Share |
|---|---|---|
| Active learning | 4 | 13.3% |
| generative models | 4 | 13.3% |
| structure prediction | 4 | 13.3% |
| Structural biology | 2 | 6.7% |
| high-throughput experiments | 2 | 6.7% |
| distributed training | 2 | 6.7% |
| Affinity maturation | 2 | 6.7% |
| antibody design | 2 | 6.7% |
| antibody engineering | 2 | 6.7% |
| biomolecules | 2 | 6.7% |
| Protein conformational dynamics | 2 | 6.7% |
| diffusion | 2 | 6.7% |
Other top cities hiring Principal Scientist
| Name | Postings | Share |
|---|---|---|
| Boston | 4 | 23.5% |
| Seattle | 3 | 17.6% |
| Beijing | 2 | 11.8% |
| Cambridge | 2 | 11.8% |
| London | 1 | 5.9% |
| Mountain View | 1 | 5.9% |
| New York City | 1 | 5.9% |
| Noida | 1 | 5.9% |
| Thousand Oaks | 1 | 5.9% |
| Waltham | 1 | 5.9% |
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How this was computed
Counts derive from the Skillenai jobs index over the 90 days ending 2026-05-17, filtered to postings whose canonical role is “Principal Scientist” and whose locationCity is “San Francisco”.
- city
- San Francisco
- role
- Principal Scientist
- source
- Skillenai jobs index, deduplicated daily
- data_as_of
- 2026-05-17
- window_days
- 90
The demand, skills, and geo numbers on this page come from the same Skillenai labor market index that powers our API. Use it for compensation benchmarking, hiring-competition analysis, and skill-adoption tracking.
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